Cavernosal Oxygenation This is the concept that the penis is a large vein in the flaccid state and a large artery in the erect state. In the flaccid state, the pO2 is approximately 35–40 mmHg. It has been postulated that this results in upregulation of fibrogenic cytokines including TGF-beta. TGF-Beta results in collagen production which […]

Fact: Men’s Sexuality Is Complex An honest model for men’s sexual health grapples with its complexity. We are not the simple, testosterone-driven, google-eyed, lap dogs for women portrayed in beer commercials. Men who model their sex on a Bud Light commercial (think wet T-shirt contest and female mud wrestling) may have fun in college, but […]

The pathophysiology of ED after radical prostatectomy involves three factors: namely, neural injury, vascular injury, and smooth muscle damage. It is well appreciated by every urologist that thermal injury to the cavernous nerves result in permanent loss of erectile function after surgery. What is less appreciated is the concept that traction on the nerves may […]

If there were no differences between humans, scientific research would be extremely easy. Any one subject could be exposed to an intervention, and that one subject’s intervention outcome could be extrapolated to the general population. Of course this is not the case, and we are faced with numerous challenges on how to infer study findings […]

Hypertension Erectile dysfunction and hypertension are widely acknowledged to be associated, but there have been relatively few experimental investigations into the mechanisms. The animal model of hypertension most widely used to assess erectile function is the spontaneously hypertensive rat (SHR). A small number of investigations have also assessed the impact of secondary hypertension due to […]